Le SIDA au Ghana (serveur d'exploration)

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Effect of vitamin A supplementation in women of reproductive age on cause-specific early and late infant mortality in rural Ghana: ObaapaVitA double-blind, cluster-randomised, placebo-controlled trial

Identifieur interne : 000733 ( Main/Exploration ); précédent : 000732; suivant : 000734

Effect of vitamin A supplementation in women of reproductive age on cause-specific early and late infant mortality in rural Ghana: ObaapaVitA double-blind, cluster-randomised, placebo-controlled trial

Auteurs : Karen Edmond [Royaume-Uni] ; Lisa Hurt [Royaume-Uni] ; Justin Fenty [Royaume-Uni] ; Seeba Amenga-Etego [Ghana] ; Charles Zandoh [Ghana] ; Chris Hurt [Royaume-Uni] ; Samuel Danso [Ghana] ; Charlotte Tawiah [Ghana] ; Zelee Hill [Royaume-Uni] ; Augustinus H A. Ten Asbroek [Royaume-Uni] ; Seth Owusu-Agyei [Ghana] ; Oona Campbell [Royaume-Uni] ; Betty R. Kirkwood [Royaume-Uni]

Source :

RBID : PMC:3330261

Abstract

Objectives

To assess the effect of vitamin A supplementation in women of reproductive age in Ghana on cause- and age-specific infant mortality. In addition, because of recently published studies from Guinea Bissau, effects on infant mortality by sex and season were assessed.

Design

Double-blind, cluster-randomised, placebo-controlled trial.

Setting

7 contiguous districts in the Brong Ahafo region of Ghana.

Participants

All women of reproductive age (15–45 years) resident in the study area randomised by cluster of residence. All live born infants from 1 June 2003 to 30 September 2008 followed up through 4-weekly home visits.

Intervention

Weekly low-dose (25 000 IU) vitamin A.

Main outcome measures

Early infant mortality (1–5 months); late infant mortality (6–11 months); infection-specific infant mortality (0–11 months).

Results

1086 clusters, 62 662 live births, 52 574 infant-years and 3268 deaths yielded HRs (95% CIs) comparing weekly vitamin A with placebo: 1.04 (0.88 to 1.05) early infant mortality; 0.99 (0.84 to 1.18) late infant mortality; 1.03 (0.92 to 1.16) infection-specific infant mortality. There was no evidence of modification of the effect of vitamin A supplementation on infant mortality by sex (Wald statistic =0.07, p=0.80) or season (Wald statistic =0.03, p=0.86).

Conclusions

This is the largest analysis of cause of infant deaths from Africa to date. Weekly vitamin A supplementation in women of reproductive age has no beneficial or deleterious effect on the causes of infant death to age 6 or 12 months in rural Ghana.

Trial registration number

http://ClinicalTrials.gov: NCT00211341.


Url:
DOI: 10.1136/bmjopen-2011-000658
PubMed: 22218721
PubMed Central: 3330261


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Hurt, Chris" sort="Hurt, Chris" uniqKey="Hurt C" first="Chris" last="Hurt">Chris Hurt</name>
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<name sortKey="Danso, Samuel" sort="Danso, Samuel" uniqKey="Danso S" first="Samuel" last="Danso">Samuel Danso</name>
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<name sortKey="Ten Asbroek, Augustinus H A" sort="Ten Asbroek, Augustinus H A" uniqKey="Ten Asbroek A" first="Augustinus H A" last="Ten Asbroek">Augustinus H A. Ten Asbroek</name>
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<region type="région" nuts="1">Grand Londres</region>
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<name sortKey="Owusu Agyei, Seth" sort="Owusu Agyei, Seth" uniqKey="Owusu Agyei S" first="Seth" last="Owusu-Agyei">Seth Owusu-Agyei</name>
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<name sortKey="Campbell, Oona" sort="Campbell, Oona" uniqKey="Campbell O" first="Oona" last="Campbell">Oona Campbell</name>
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<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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<name sortKey="Kirkwood, Betty R" sort="Kirkwood, Betty R" uniqKey="Kirkwood B" first="Betty R" last="Kirkwood">Betty R. Kirkwood</name>
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<region type="région" nuts="1">Grand Londres</region>
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<series>
<title level="j">BMJ Open</title>
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<div type="abstract" xml:lang="en">
<sec>
<title>Objectives</title>
<p>To assess the effect of vitamin A supplementation in women of reproductive age in Ghana on cause- and age-specific infant mortality. In addition, because of recently published studies from Guinea Bissau, effects on infant mortality by sex and season were assessed.</p>
</sec>
<sec>
<title>Design</title>
<p>Double-blind, cluster-randomised, placebo-controlled trial.</p>
</sec>
<sec>
<title>Setting</title>
<p>7 contiguous districts in the Brong Ahafo region of Ghana.</p>
</sec>
<sec>
<title>Participants</title>
<p>All women of reproductive age (15–45 years) resident in the study area randomised by cluster of residence. All live born infants from 1 June 2003 to 30 September 2008 followed up through 4-weekly home visits.</p>
</sec>
<sec>
<title>Intervention</title>
<p>Weekly low-dose (25 000 IU) vitamin A.</p>
</sec>
<sec>
<title>Main outcome measures</title>
<p>Early infant mortality (1–5 months); late infant mortality (6–11 months); infection-specific infant mortality (0–11 months).</p>
</sec>
<sec>
<title>Results</title>
<p>1086 clusters, 62 662 live births, 52 574 infant-years and 3268 deaths yielded HRs (95% CIs) comparing weekly vitamin A with placebo: 1.04 (0.88 to 1.05) early infant mortality; 0.99 (0.84 to 1.18) late infant mortality; 1.03 (0.92 to 1.16) infection-specific infant mortality. There was no evidence of modification of the effect of vitamin A supplementation on infant mortality by sex (Wald statistic =0.07, p=0.80) or season (Wald statistic =0.03, p=0.86).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>This is the largest analysis of cause of infant deaths from Africa to date. Weekly vitamin A supplementation in women of reproductive age has no beneficial or deleterious effect on the causes of infant death to age 6 or 12 months in rural Ghana.</p>
</sec>
<sec>
<title>Trial registration number</title>
<p>
<ext-link ext-link-type="uri" xlink:href="http://ClinicalTrials.gov">http://ClinicalTrials.gov</ext-link>
: NCT00211341.</p>
</sec>
</div>
</front>
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<name sortKey="Beaton, Gh" uniqKey="Beaton G">GH Beaton</name>
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<name sortKey="Martorell, R" uniqKey="Martorell R">R Martorell</name>
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<name sortKey="Amenga Etego, Seeba" sort="Amenga Etego, Seeba" uniqKey="Amenga Etego S" first="Seeba" last="Amenga-Etego">Seeba Amenga-Etego</name>
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</record>

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